A few weeks ago, the news wires picked up a story
concerning the discovery of a gonorrhea super-bug that is resistant to most
forms of antibiotics. The headlines screamed: “Worse Than AIDS.” Almost
immediately, the CDC was quick to respond: stating that the deadly strain had
not been detected in the US. Yet! Right way, I am reminded of the early
reports, when I was a kid, on the emergence of a new “gay cancer.” It hadn’t
been designated AIDS yet. The news reporters said that the disease was
localized in gay male populations and among Haitians. Everyone breathed a sigh
of relief. Now, 30 years later, and after the death of millions, we know the
truth.
Since 1986, the United States Gonococcal Isolate
Surveillance Project (GISP) has been monitoring antibiotic resistance to
gonorrhea. According to GISP, by 2010, 27% of all of the
gonorrhea samples were resistant to penicillin, tetracycline, and ciprofloxacin,
or some combination of these drugs. By 2010, 27% of all gonorrhea tested was
resistant to three major antibiotics or some combination of these drugs.
Cefixime, an oral cephalosporin antibiotic (cephalosporins are a sub-group of
beta-lactam antibiotics, like carbapenems) was the recommended antibiotic for
gonorrhea treatment, until gonorrhea began to develop resistance that drug too.
In 2012, the CDC updated its treatment guidelines and now recommends an
injectable cephalosporin, called ceftriaxone, along with azithromycin or
doxycycline, instead of oral cephalosporins. Combination therapies (meaning
more than one antibiotic) provide almost a one-two punch against these
bacteria—so the hope is that this remains effective. But cephalosporins are our
last line of antibiotic defense against gonorrhea. As authors wrote in 2012 in
a piece in the New England Journal of Medicine, it is now “time to sound the
alarm.” Simply put, the outlook is not good. In 2011, doctors from Japan
published a case study revealing that gonorrhea was acquiring even more
resistance—this time, to injectable ceftriaxone. Since then, samples of
ceftriaxone-resistant gonorrhea have been detected in France and Spain, too,
reports the CDC.
*Authors Note: About 20 years
ago, I caught this disease. It was pure agony. At the time, I was mentally
deranged; therefore I didn’t take very good care of myself. When I finally
visited a physician, I had been sick for at least a few months. It took several
courses of different antibiotics to eventually rid my body of the infection.
While on the medication, I was constantly in pain, couldn’t stop having
diarrhea, and lost a lot of weight. Now, it all reminds me of what a dear
friend said to me, while he was dying with AIDS: “It wasn’t worth it.”







